Last edited by Doulkis
Wednesday, May 6, 2020 | History

2 edition of Carcinogenic potential of rotenone found in the catalog.

Carcinogenic potential of rotenone

Ralph I Freudenthal

Carcinogenic potential of rotenone

subchronic oral and peritoneal administration to rats and chronic dietary administration to syrian golden hamsters

by Ralph I Freudenthal

  • 32 Want to read
  • 17 Currently reading

Published by U.S. Environmental Protection Agency, Health Effects Research Laboratory, Center for Environmental Research Information [distributor] in Research Triangle Park, NC, Cincinnati, OH .
Written in English

    Subjects:
  • Carcinogenicity testing,
  • Rotenone

  • Edition Notes

    StatementR.I. Freudenthal, D.C. Thake, and R.L. Baron
    ContributionsThake, D. C, Baron, R. L, Health Effects Research Laboratory (Research Triangle Park, N.C.)
    The Physical Object
    Pagination6 p. ;
    ID Numbers
    Open LibraryOL14893170M

    teratogenic, mutagenic, or carcinogenic effects, particularly at piscicidal concentrations. There is no data that suggests that rotenone is an endocrine disruptor. Environmental fate of rotenone in natural water systems. Rotenone is difficult to handle in the pure state, as it is sensitive to light and oxygen, quickly decomposing to less toxic. The edition lists 62 known human carcinogens and includes descriptions of the process for preparing the science-based report and the criteria used to list a substance as a carcinogen. IARC also produces science-based reports on substances that can increase the risk of cancer in humans.

    Chapter: Measures of Carcinogenic Potency Get This Book Visit to get more information about this book, to buy it in print, or to download it as a free PDF. Role of the Mitochondrial Membrane Permeability Transition (MPT) in Rotenone-Induced Apoptosis in Liver Cells Article (PDF Available) in Toxicological Sciences 53(2) March with

    manuscript again before final publication of the book, and also contributed to the Advisory Group’s recommendations cancer bioassays, and data elucidating potential mechanisms of carcinogenicity of compounds related to air pollution. These presentations were followed by discussions in subgroups estab- Air pollution and cancer). Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells. The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances.


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Carcinogenic potential of rotenone by Ralph I Freudenthal Download PDF EPUB FB2

Carcinogenic potential of rotenone: subchronic oral and peritoneal administration to rats and chronic dietary administration to syrian golden hamsters Author: Ralph I Freudenthal ; D C Thake ; R L Baron ; Health Effects Research Laboratory (Research Triangle Park, N.C.).

Fja offspring were to be maintained on rotenone diets to determine their sensitivity to any potential carcinogenic effects of the chemical. The ppm Diet Study The first group of animals (mean body weights were 45 grams for both sexes) to be mated were maintained on a ppm rotenone diet containing 1% corn oil.

The present study aimed to investigate the effect of rotenoisin B, radialytic rotenone, on anti-carcinogenic activity and its action mechanisms in hepatic cancer cells with low toxic effect on the normal cells compared to by: 4. Fourteen-Month Oral Carcinogenesis Study A study was performed to examine the potential carcinogenicity of rotenone in a second strain of rats.

This study employed oral gavage as the route of administration, again in an attempt to duplicate the studies of Gosalvez and Merchan. Carcinogenicity The potential carcinogenicity of rotenone was evalu- ated by Innes et al.

() in two strains of mice by oral intubation of the test materials in a O.5~O suspension in a gelatin vehicle.

A dose of 1 mg/kg was administered daily to 7-day-old mice until they were 4 weeks old. Novel Radiolytic Rotenone Derivative, Rotenoisin B with Potent Anti-Carcinogenic Activity in Hepatic Cancer Cells Srilatha Badaboina 1,†, Hyoung-Woo Bai 1,†, Yun Hee Na 1,2, Chul-Hong Park 1,3, Tae Hoon Kim 4.

It is strongly suggested that rotenone is carcinogenic to the rat (at doses from 2 to 25 parts per million continuously in food, or from to mg/kg weight for 1 to 4 months by oral administration), above all, when the rats receive deficient diets, especially those poor in riboflavin.

Rotenone is a rotenoid plant extract obtained from such species as barbasco, cub, haiari, nekoe, and timbo.

These plants are members of the pea (Leguminosae) family. Rotenone containing extracts are taken from the roots, seeds and leaves of the various plants. Rotenone is generally classified as a botanical insecticide. Rotenone is not considered to be carcinogenic. Recent experimental findings linking it to Parkinsonian effects seem unlikely to occur under normal uses.

Rotenone is a potent botanical pesticide that has become a source of mounting concern because of its toxicity and potential environmental impact.

Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment. Editors About this book. mutagenic and carcinogenic potentials are not fully understood, and any thorough investigation demands the combined efforts of scientists drawn from many different disciplines.

The present study aimed to investigate the effect of rotenoisin B, radialytic rotenone, on anti-carcinogenic activity and its action mechanisms in hepatic cancer cells with low toxic effect on the normal cells compared to by: 4. Our investigation into the carcinogenic potential of ro- tenone began after reviewing the dissertation by a student ofGosalvez (Diaz-Gil, ), which revealed that rotenone had been dissolved in chloroform and added to sunflower (SF) oil prior to treatment of rats.

Since its inception in the early 's, Sax's Dangerous Properties of Industrial Materials has become the primary source for those who need to evaluate the hazardous potential of substances used in 's is the only reference that combines data on toxicology, flammability, reactivity, explosive potential, and regularity information for o substances.

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Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment: 2 (Closed)) (Nato Science Partnership Subseries: 2): Medicine & Health Science Books Format: Paperback.

View The Lancet Oncology summary as HTML or PDF. French version of The Lancet Oncology summary (hosted by Centre Léon Bérard). This volume of the IARC Monographs provides evaluations of the consumption of red meat and the consumption of processed meat.

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This monograph re-evaluates the potential carcinogenic hazards to humans from exposure to inorganic and organic lead compounds. Human exposure comes from lead-contaminated air, dust, soil, water and food and through inhalation and ingestion. Recent human exposure has arisen predominantly from the widespread use of leaded gasoline.

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Since rotenone has also shown anti-carcinogenic activity in several stud22,23,24, the aim of the present study was to identify biomarker candidates and provide enhanced mechanistic insights.

Carcinogenic Risk Factors JMAJ 44(6): –, Hiroshi SAEKI* and Keizo SUGIMACHI** *Assistant Professor and **Professor, Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University Abstract: Carcinogenic risk factors can be roughly divided into environmental factors and genetic factors.Rotenone Characterization and Toxicity in Aquatic Systems Dustin Hinson University of Idaho Principles of Environmental Toxicology November, Abstract Rotenone is a compound that has been used by fisheries managers since the ’s as a piscicide, or fish .Registration and Checkout.

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